Blar i forfatter "Mönkemöller, Viola"

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    • Multimodal super-resolution optical microscopy visualizes the close connection between membrane and the cytoskeleton in liver sinusoidal endothelial cell fenestrations 

      Mönkemöller, Viola; Øie, Cristina Ionica; Hubner, Wolfgang; Huser, Thomas Rolf; McCourt, Peter Anthony (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
      Liver sinusoidal endothelial cells (LSECs) act as a filter between blood and the hepatocytes. LSECs are highly fenestrated cells; they contain transcellular pores with diameters between 50 to 200 nm. The small sizes of the fenestrae have so far prohibited any functional analysis with standard and advanced light microscopy techniques. Only the advent of super-resolution optical fluorescence microscopy ...

    • Multiscale and Multimodal Optical Imaging of the Ultrastructure of Human Liver Biopsies 

      Kong, Cihang; Bobe, Stefanie; Pilger, Christian; Lachetta, Mario; Øie, Cristina Ionica; Kirschnick, Nils; Mönkemöller, Viola; Hübner, Wolfgang; Förster, Christine; Schuttpelz, Mark; Kiefer, Friedemann; Huser, Thomas; Schulte am Esch, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-17)
      The liver as the largest organ in the human body is composed of a complex macroscopic and microscopic architecture that supports its indispensable function to maintain physiological homeostasis. Optical imaging of the human liver is particularly challenging because of the need to cover length scales across 7 orders of magnitude (from the centimeter scale to the nanometer scale) in order to fully ...

    • New ways of looking at very small holes – using optical nanoscopy to visualize liver sinusoidal endothelial cell fenestrations 

      Øie, Cristina Ionica; Mönkemöller, Viola; Hübner, Wolfgang; Schüttpelz, Mark; Mao, Hong; Ahluwalia, Balpreet Singh; Huser, Thomas Rolf; McCourt, Peter Anthony (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-10)
      Super-resolution fluorescence microscopy, also known as nanoscopy, has provided us with a glimpse of future impacts on cell biology. Far-field optical nanoscopy allows, for the first time, the study of sub-cellular nanoscale biological structures in living cells, which in the past was limited to electron microscopy (EM) (in fixed/dehydrated) cells or tissues. Nanoscopy has particular utility in the ...

    • Primary rat LSECs preserve their characteristic phenotype after cryopreservation 

      Mönkemöller, Viola; Mao, Hong; Hubner, Wolfgang; Heimann, Peter; Levy, Gahl; Huser, Thomas; Kaltschmidt, Barbara; Kaltschmidt, Christian; Øie, Cristina Ionica (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-02)
      Liver disease is a leading cause of morbidity and mortality worldwide. Recently, the liver non-parenchymal cells have gained increasing attention for their potential role in the development of liver disease. Liver sinusoidal endothelial cells (LSECs), a specialized type of endothelial cells that have unique morphology and function, play a fundamental role in maintaining liver homeostasis. Current ...